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Contributor submission PaaA #911

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Contributor submission PaaA #911

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c3fe1b1
Add submission UUID file
mite-bot Sep 14, 2026
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Update submission
mite-bot Sep 14, 2026
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66 changes: 66 additions & 0 deletions mite_data/data/163ea9fa-b04a-11f1-b4b1-cf84655b59e7.json
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{
"accession": "MITE9999999",
"status": "pending",
"comment": "PaaA catalyzes dual dehydration and decarboxylation of two glutamic acid residues on the EEN core of the precursor peptide to generate a bicyclic structure in the biosynthesis of Pantocin A",
"changelog": [
{
"version": "1",
"date": "2026-09-14",
"contributors": [
"0009-0008-8086-5325"
],
"reviewers": [
"BBBBBBBBBBBBBBBBBBBBBBBB"
],
"comment": "New entry."
}
],
"enzyme": {
"name": "PaaA",
"description": "ThiF/E1 like enzyme family",
"references": [
"doi:10.1021/acschembio.6c00650",
"doi:10.1021/jacs.5b13529"
],
"databaseIds": {
"uniprot": "UPI0006DD4730",
"genpept": "KPA06477.1",
"mibig": "BGC0002317"
},
"cofactors": {
"organic": [
"Adenosine triphosphate"
]
}
},
"reactions": [
{
"tailoring": [
"Cyclization",
"Decarboxylation",
"Dehydration"
],
"description": "PaaA catalyzes the double dehydration and decarboxylation of two Glu residues (E16 and E17) to form a bicyclic core of Pantocin A",
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"reactions": [
{
"substrate": "CCC(C)C(NC(=O)C(N)CCSC)C(=O)NC(CCCCN)C(=O)NC(Cc1ccccc1)C(=O)NC(CO)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(CO)C(=O)NC(C)C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(C)C(=O)NC(CCSC)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCC(N)=O)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)O)C(C)C)C(C)CC)C(C)C)C(C)O)C(C)O)C(C)CC)C(C)CC)C(C)O",
"products": [
"CCC(C)C(NC(=O)C(N)CCSC)C(=O)NC(CCCCN)C(=O)NC(Cc1ccccc1)C(=O)NC(CO)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(CO)C(=O)NC(C)C(=O)NC(C(=O)NC(C(=O)NC1CCC2=CCC(C(=O)NC(CC(N)=O)C(=O)NC(C)C(=O)NC(CCSC)C(=O)NC(Cc3ccc(O)cc3)C(=O)NC(C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCC(N)=O)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)O)C(C)C)C(C)CC)C(C)C)C(C)O)N2C1=O)C(C)O)C(C)CC)C(C)CC)C(C)O"
],
"isIntermediate": true,
"description": "PaaP precursor peptide: MIKFSTLSQRISAITEENAMYTKGQVIVLS"
}
],
"evidence": {
"evidenceCode": [
"In vitro assay"
],
"references": [
"doi:10.1021/acschembio.6c00650",
"doi:10.1021/jacs.5b13529"
]
}
}
]
}
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