mite-standard · mite-bot · Jul 24, 2026 · Jul 24, 2026 · Aug 19, 2026 · Aug 19, 2026
diff --git a/mite_data/data/MITE9999999.json b/mite_data/data/MITE9999999.json
@@ -0,0 +1,66 @@
+{
+    "accession": "MITE9999999",
+    "status": "active",
+    "comment": "Biaryl C\u2013N cross-link between Y-W on the YPW motif",
+    "changelog": [
+        {
+            "version": "1",
+            "date": "2026-07-24",
+            "contributors": [
+                "0009-0008-8086-5325"
+            ],
+            "reviewers": [
+                "0009-0008-6482-7206",
+                "0000-0001-6534-6609"
+            ],
+            "comment": "New entry. Reviewer 1 corrected product SMILES."
+        }
+    ],
+    "enzyme": {
+        "name": "SalP",
+        "description": "Cytochrome P450",
+        "references": [
+            "doi:10.1021/jacs.3c07416"
+        ],
+        "databaseIds": {
+            "uniprot": "UPI000B1CBA07",
+            "genpept": "QRV29427.1"
+        },
+        "cofactors": {
+            "organic": [
+                "Heme"
+            ],
+            "inorganic": [
+                "Fe"
+            ]
+        }
+    },
+    "reactions": [
+        {
+            "tailoring": [
+                "Biaryl bond formation"
+            ],
+            "description": "SalP catalyzes a C\u2013N cross-link between the phenyl ring of tyrosine and the indole ring of tryptophan",
+            "reactionSMARTS": "[#6:1]-[#6:2]-[#6@@:3](-[#6@@:5](/[#6:204](-[#7:206]1-[#6@:210](/[#6:211](-[#8:213])=[#8:212])-[#6:209]-[#6:208]-[#6:207]-1)=[#8:205])-[#7:6]-[#6:7](/[#6@@:9](-[#7:20]-[#6:21](\\[#6@:23]1-[#7:27](-[#6:28](\\[#6@@:30](-[#7:39]-[#6:40](-[#6@@:42](-[#7:44]-[#6:45](-[#6:47]-[#7:48]-[#6:49](-[#6@@:51](-[#7:53]-[#6:54](-[#6@@:56](-[#7:58]-[#6:59](-[#6:61]-[#7:62]-[#6:63](/[#6@@:65](-[#7:71]-[#6:72](\\[#6@:74](-[#6@:201](-[#8:203])/[#6:202])-[#7:75]-[#6:76](/[#6@:78](-[#6@:198](-[#8:200])\\[#6:199])-[#7:79]-[#6:80](/[#6@@:82](-[#7:90]-[#6:91](-[#6:93]-[#7:94]-[#6:95](\\[#6@@:97](-[#7:102]-[#6:103](\\[#6@@:105](-[#7:111]-[#6:112](/[#6@@:114](-[#7:117]-[#6:118](-[#6@@:120](-[#7:122]-[#6:123](-[#6@@:125](-[#7:127]-[#6:128](\\[#6@@:130](-[#7:136]-[#6:137](/[#6@@:139](-[#7:148]-[#6:149](\\[#6@@:151](-[#7:156]-[#6:157](/[#6@@:159](-[#7:164]-[#6:165](\\[#6@@:167](-[#7:175]-[#6:176](/[#6@@:178](-[#7:184]-[#6:185](-[#6@@:187](-[#7:189]-[#6:190](-[#6@:192](-[#6:194]-[#6:195]-[#16:196]-[#6:197])\\[#7:193])=[#8:191])\\[#6:188])=[#8:186])-[#6:179]-[#6:180]-[#6:181]-[#6:182]-[#7:183])=[#8:177])-[#6:168]-[#6:169]-[#6:170]-[#7:171]-[#6:172](-[#7:174])=[#7:173])=[#8:166])-[#6:160]-[#6:161]-[#16:162]-[#6:163])=[#8:158])-[#6:152]-[#6:153](-[#6:155])-[#6:154])=[#8:150])-[#6:140]-[#6:141]2:[#6:147]:[#6:146]:[#6:144](-[#8:145]):[#6:143]:[#6:142]:2)=[#8:138])-[#6:131]-[#6:132]-[#6:133]-[#6:134]-[#7:135])=[#8:129])/[#6:126])=[#8:124])\\[#6:121])=[#8:119])-[#6:115]-[#8:116])=[#8:113])-[#6:106]-[#6:107]-[#6:108]-[#6:109]-[#7:110])=[#8:104])-[#6:98]-[#6:99](-[#6:101])-[#6:100])=[#8:96])=[#8:92])-[#6:83]-[#6:84]2:[#6:89]:[#6:88]:[#6:87]:[#6:86]:[#6:85]:2)=[#8:81])=[#8:77])=[#8:73])-[#6:66]-[#6:67]-[#6:68]-[#6:69]-[#7:70])=[#8:64])=[#8:60])/[#6:57])=[#8:55])\\[#6:52])=[#8:50])=[#8:46])\\[#6:43])=[#8:41])-[#6:31]-[#6:32]2:[#6:38]:[#6:37]:[#6:35](-[#8:36]):[#6:34]:[#6:33]:2)=[#8:29])-[#6:26]-[#6:25]-[#6:24]-1)=[#8:22])-[#6:10]-[#6:11]1:[#6:19]2:[#6:14](:[#6:15]:[#6:16]:[#6:17]:[#6:18]:2):[#7:13]:[#6:12]:1)=[#8:8])/[#6:4]>>[#6:1]-[#6:2]-[#6@@:3](-[#6@@:5](/[#6:204](-[#7:206]1-[#6@:210](/[#6:211](-[#8:213])=[#8:212])-[#6:209]-[#6:208]-[#6:207]-1)=[#8:205])-[#7:6]-[#6:7](/[#6@:9]1-[#7:20]-[#6:21](\\[#6@:23]2-[#7:27](-[#6:28](\\[#6@@:30](-[#7:39]-[#6:40](-[#6@@:42](-[#7:44]-[#6:45](-[#6:47]-[#7:48]-[#6:49](-[#6@@:51](-[#7:53]-[#6:54](-[#6@@:56](-[#7:58]-[#6:59](-[#6:61]-[#7:62]-[#6:63](/[#6@@:65](-[#7:71]-[#6:72](\\[#6@:74](-[#6@:201](-[#8:203])/[#6:202])-[#7:75]-[#6:76](/[#6@:78](-[#6@:198](-[#8:200])\\[#6:199])-[#7:79]-[#6:80](/[#6@@:82](-[#7:90]-[#6:91](-[#6:93]-[#7:94]-[#6:95](\\[#6@@:97](-[#7:102]-[#6:103](\\[#6@@:105](-[#7:111]-[#6:112](/[#6@@:114](-[#7:117]-[#6:118](-[#6@@:120](-[#7:122]-[#6:123](-[#6@@:125](-[#7:127]-[#6:128](\\[#6@@:130](-[#7:136]-[#6:137](/[#6@@:139](-[#7:148]-[#6:149](\\[#6@@:151](-[#7:156]-[#6:157](/[#6@@:159](-[#7:164]-[#6:165](\\[#6@@:167](-[#7:175]-[#6:176](/[#6@@:178](-[#7:184]-[#6:185](-[#6@@:187](-[#7:189]-[#6:190](-[#6@:192](-[#6:194]-[#6:195]-[#16:196]-[#6:197])\\[#7:193])=[#8:191])\\[#6:188])=[#8:186])-[#6:179]-[#6:180]-[#6:181]-[#6:182]-[#7:183])=[#8:177])-[#6:168]-[#6:169]-[#6:170]-[#7:171]-[#6:172](-[#7:174])=[#7:173])=[#8:166])-[#6:160]-[#6:161]-[#16:162]-[#6:163])=[#8:158])-[#6:152]-[#6:153](-[#6:154])-[#6:155])=[#8:150])-[#6:140]-[#6:141]3:[#6:142]:[#6:143]:[#6:144](-[#8:145]):[#6:146]:[#6:147]:3)=[#8:138])-[#6:131]-[#6:132]-[#6:133]-[#6:134]-[#7:135])=[#8:129])/[#6:126])=[#8:124])\\[#6:121])=[#8:119])-[#6:115]-[#8:116])=[#8:113])-[#6:106]-[#6:107]-[#6:108]-[#6:109]-[#7:110])=[#8:104])-[#6:98]-[#6:99](-[#6:101])-[#6:100])=[#8:96])=[#8:92])-[#6:83]-[#6:84]3:[#6:85]:[#6:86]:[#6:87]:[#6:88]:[#6:89]:3)=[#8:81])=[#8:77])=[#8:73])-[#6:66]-[#6:67]-[#6:68]-[#6:69]-[#7:70])=[#8:64])=[#8:60])/[#6:57])=[#8:55])\\[#6:52])=[#8:50])=[#8:46])\\[#6:43])=[#8:41])-[#6:31]-[#6:32]3:[#6:38]:[#6:37](-[#7:13]4:[#6:12]:[#6:11](:[#6:19]5:[#6:14]:4:[#6:15]:[#6:16]:[#6:17]:[#6:18]:5)-[#6:10]-1):[#6:35](-[#8:36]):[#6:34]:[#6:33]:3)=[#8:29])-[#6:26]-[#6:25]-[#6:24]-2)=[#8:22])=[#8:8])/[#6:4]",
+            "reactions": [
+                {
+                    "substrate": "CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)[C@@H](C)O)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)O",
+                    "products": [
+                        "CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2cn(c3ccccc23)-c2cc(ccc2O)C[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)[C@@H](C)O)[C@@H](C)O)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N1CCC[C@H]1C(=O)O"
+                    ],
+                    "isIntermediate": true,
+                    "description": "SalP catalyzes a C\u2013N cross-link between Tyr-Trp on the precursor peptide SalA, before the release of mature crosslinked peptide YPWIP"
+                }
+            ],
+            "evidence": {
+                "evidenceCode": [
+                    "Heterologous expression",
+                    "In vitro assay"
+                ],
+                "references": [
+                    "doi:10.1021/jacs.3c07416"
+                ]
+            }
+        }
+    ]
+}