Contributor submission PhomQ2

mite_data/data/MITE0000482.json

@@ -0,0 +1,64 @@
+{
+    "accession": "MITE0000482",
+    "status": "active",
+    "comment": "Tyrosinase-like protein, also annotated as Oxidoreductase that oxidases/hydroxylates the tyrosine",
+    "changelog": [
+        {
+            "version": "1",
+            "date": "2026-05-06",
+            "contributors": [
+                "0009-0008-4645-6771"
+            ],
+            "reviewers": [
+                "0000-0002-9747-3423",
+                "0000-0001-6534-6609"
+            ],
+            "comment": "New entry. Reviewer 2 changed reaction SMILES to reaction SMARTS."
+        }
+    ],
+    "enzyme": {
+        "name": "PhomQ2",
+        "description": "Monooxygenase, Oxidoreductase",
+        "references": [
+            "doi:10.1002/anie.202111076"
+        ],
+        "databaseIds": {
+            "uniprot": "A0A8J9RRY2",
+            "genpept": "BDA39150.1",
+            "mibig": "BGC0001398"
+        },
+        "cofactors": {
+            "inorganic": [
+                "Cu"
+            ]
+        }
+    },
+    "reactions": [
+        {
+            "tailoring": [
+                "Hydroxylation",
+                "Oxidation"
+            ],
+            "description": "Hydroxylation of the tyrosine moiety",
+            "reactionSMARTS": "[#6:1]-[#6:2]-[#6@@:3](-[#6@@:5](\\[#6:42](-[#7:44]/[#6@:45](-[#6:50](-[#8:52])=[#8:51])-[#6:46]-[#6:47](-[#8:49])=[#8:48])=[#8:43])-[#7:6]-[#6:7](/[#6@:9]1-[#7:13](-[#6:14](/[#6@:16](-[#6@:38](-[#6:40]-[#6:41])/[#6:39])-[#7:17]-[#6:18](\\[#6@:20](-[#6:35](-[#6:37])-[#6:36])-[#7:21]-[#6:22](-[#6@:24](-[#6:26]-[#6:27]2:[#6:34]:[#6:32](-Cl:33):[#6:30](-[#8:31]):[#6:29]:[#6:28]:2)\\[#7:25])=[#8:23])=[#8:19])=[#8:15])-[#6:12]-[#6:11]-[#6:10]-1)=[#8:8])\\[#6:4]>>[#6:1]-[#6:2]-[#6@@:3](-[#6@@:5](\\[#6:42](-[#7:44]/[#6@:45](-[#6:50](-[#8:52])=[#8:51])-[#6:46]-[#6:47](-[#8:49])=[#8:48])=[#8:43])-[#7:6]-[#6:7](/[#6@:9]1-[#7:13](-[#6:14](/[#6@:16](-[#6@:38](-[#6:40]-[#6:41])/[#6:39])-[#7:17]-[#6:18](\\[#6@:20](-[#6:35](-[#6:36])-[#6:37])-[#7:21]-[#6:22](-[#6@:24](-[#6:26]-[#6:27]2:[#6:34]:[#6:32](-Cl:33):[#6:30](-[#8:31]):[#6:29](-[#8]):[#6:28]:2)\\[#7:25])=[#8:23])=[#8:19])=[#8:15])-[#6:12]-[#6:11]-[#6:10]-1)=[#8:8])\\[#6:4]",
+            "reactions": [
+                {
+                    "substrate": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O",
+                    "products": [
+                        "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cc(O)c(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O"
+                    ],
+                    "isIntermediate": false,
+                    "description": "Hydroxylation of the tyrosine moiety"
+                }
+            ],
+            "evidence": {
+                "evidenceCode": [
+                    "Knock-out studies"
+                ],
+                "references": [
+                    "doi:10.1002/anie.202111076"
+                ]
+            }
+        }
+    ]
+}