feat: add bioequivalence inferential statistics functions#547
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feat: add bioequivalence inferential statistics functions#547billdenney wants to merge 1 commit into
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Add fitbe_models(), fitbe_table(), and fitbe_calculate() to compute average bioequivalence statistics from NCA results: per-endpoint linear mixed-effects models on log-transformed values, geometric mean ratios with 90 percent confidence intervals, Satterthwaite degrees of freedom, and intra-subject CV. The functions consume the long-format output of a PKNCAresults object directly. The statistical engine packages (lme4, lmerTest, emmeans) are Suggests and guarded with requireNamespace(); tests skip when they are absent. Adds the v50-bioequivalence vignette, tests, and documentation. Formalizes the prototype workflow from PR 490. Co-Authored-By: Claude Opus 4.7 (1M context) <noreply@anthropic.com>
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Based on the functions @Sang-j111 build in #490 |
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Add fitbe_models(), fitbe_table(), and fitbe_calculate() to compute average bioequivalence statistics from NCA results: per-endpoint linear mixed-effects models on log-transformed values, geometric mean ratios with 90 percent confidence intervals, Satterthwaite degrees of freedom, and intra-subject CV. The functions consume the long-format output of a PKNCAresults object directly.
The statistical engine packages (lme4, lmerTest, emmeans) are Suggests and guarded with requireNamespace(); tests skip when they are absent. Adds the v50-bioequivalence vignette, tests, and documentation. Formalizes the prototype workflow from PR 490.