shanethacker · Feb 2, 2026 · Jan 30, 2026
diff --git a/compose/example.env b/compose/example.env
@@ -26,7 +26,7 @@ DJANGO_HTTPS_ONLY=False
 DJANGO_EMAIL_BACKEND=CONSOLE
 ADMIN_URL_PREFIX=c6cbceb2-0592-497b-bd92-5d881a1fae40
 PUBMED_API_KEY=8852fcfa8cc0850a16d7e24d21e23f77
-CCTE_API_KEY=0468d596fe45f2e7b562318d80b11ea2
+EPA_COMPTOX_API_KEY=0468d596fe45f2e7b562318d80b11ea2
 HAWC_SESSION_DURATION=604800
 HAWC_ANYONE_CAN_CREATE_ASSESSMENTS=True
 HAWC_PM_CAN_MAKE_PUBLIC=True

diff --git a/hawc/apps/assessment/models.py b/hawc/apps/assessment/models.py
@@ -110,7 +110,7 @@ def dashboard_url(self) -> str:
         return f"https://comptox.epa.gov/dashboard/chemical/details/{self.dtxsid}"
 
     def image_url(self) -> str:
-        return f"https://api-ccte.epa.gov/chemical/file/image/search/by-dtxsid/{self.dtxsid}"
+        return f"https://comptox.epa.gov/ctx-api/chemical/file/image/search/by-dtxsid/{self.dtxsid}"
 
 
 class Assessment(models.Model):

diff --git a/hawc/main/settings/base.py b/hawc/main/settings/base.py
@@ -333,7 +333,7 @@ def get_git_commit() -> Commit:
 PUBMED_MAX_QUERY_SIZE = 10000
 
 # CCTE API key
-CCTE_API_KEY = os.getenv("CCTE_API_KEY")
+EPA_COMPTOX_API_KEY = os.getenv("EPA_COMPTOX_API_KEY")
 
 # HERO API key
 HERO_API_KEY = os.getenv("HERO_API_KEY")

diff --git a/hawc/services/epa/dsstox.py b/hawc/services/epa/dsstox.py
@@ -51,11 +51,11 @@ def create_from_dtxsid(cls, dtxsid: str) -> Self:
             return cls.create_fake(dtxsid)
         if not re.compile(RE_DTXSID).fullmatch(dtxsid):
             raise ValueError(f"Invalid DTXSID: {dtxsid}")
-        if settings.CCTE_API_KEY is None and settings.IS_TESTING is False:
+        if settings.EPA_COMPTOX_API_KEY is None and settings.IS_TESTING is False:
             raise ValueError("Missing API key")
-        session = get_session(headers={"x-api-key": settings.CCTE_API_KEY})
+        session = get_session(headers={"x-api-key": settings.EPA_COMPTOX_API_KEY})
         response = session.get(
-            f"https://api-ccte.epa.gov/chemical/detail/search/by-dtxsid/{dtxsid}",
+            f"https://comptox.epa.gov/ctx-api/chemical/detail/search/by-dtxsid/{dtxsid}",
             timeout=15,
         )
         response_dict = response.json()

diff --git a/tests/data/cassettes/apps.assessment.test_api/TestDssToxViewSet.test_create_dtxsid.yaml b/tests/data/cassettes/apps.assessment.test_api/TestDssToxViewSet.test_create_dtxsid.yaml
@@ -5,85 +5,75 @@ interactions:
       Accept:
       - application/json
       Accept-Encoding:
-      - gzip, deflate
+      - gzip, deflate, zstd
       Connection:
       - keep-alive
       User-Agent:
       - hawc
       x-api-key:
       - <omitted>
     method: GET
-    uri: https://api-ccte.epa.gov/chemical/detail/search/by-dtxsid/DTXSID1020190
+    uri: https://comptox.epa.gov/ctx-api/chemical/detail/search/by-dtxsid/DTXSID1020190
   response:
     body:
-      string: "{\n  \"id\" : \"898183\",\n  \"msReadySmiles\" : \"OS(=O)(=O)C1=CC2=C(NC(C2=O)C2=NC3=C(C=C(C=C3)S(O)(=O)=O)C2=O)C=C1\",\n
-        \ \"irisLink\" : null,\n  \"pprtvLink\" : null,\n  \"descriptorStringTsv\"
-        : \"0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t1\\t1\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t1\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\",\n
-        \ \"isMarkush\" : false,\n  \"cpdataCount\" : 25,\n  \"wikipediaArticle\"
-        : \"Indigo carmine\",\n  \"inchikey\" : \"KHLVKKOJDHCJMG-UHFFFAOYSA-L\",\n
-        \ \"nhanes\" : null,\n  \"toxvalData\" : \"Y\",\n  \"waterSolubilityTest\"
-        : null,\n  \"waterSolubilityOpera\" : 0.164899,\n  \"viscosityCpCpTestPred\"
-        : null,\n  \"vaporPressureMmhgTestPred\" : null,\n  \"vaporPressureMmhgOperaPred\"
-        : 3.79111E-10,\n  \"thermalConductivity\" : null,\n  \"tetrahymenaPyriformis\"
-        : null,\n  \"surfaceTension\" : null,\n  \"soilAdsorptionCoefficient\" : 39.0955,\n
-        \ \"oralRatLd50Mol\" : null,\n  \"operaKmDaysOperaPred\" : 0.576138,\n  \"octanolWaterPartition\"
-        : 0.962405,\n  \"octanolAirPartitionCoeff\" : 9.38377,\n  \"meltingPointDegcTestPred\"
-        : null,\n  \"meltingPointDegcOperaPred\" : 228.535,\n  \"hrFatheadMinnow\"
-        : null,\n  \"hrDiphniaLc50\" : null,\n  \"henrysLawAtm\" : 1.48644E-11,\n
-        \ \"flashPointDegcTestPred\" : null,\n  \"devtoxTestPred\" : null,\n  \"density\"
-        : null,\n  \"boilingPointDegcTestPred\" : null,\n  \"boilingPointDegcOperaPred\"
-        : 291.807,\n  \"biodegradationHalfLifeDays\" : 15.3519,\n  \"bioconcentrationFactorTestPred\"
-        : null,\n  \"bioconcentrationFactorOperaPred\" : 2.42942,\n  \"atmosphericHydroxylationRate\"
-        : 4.84144E-11,\n  \"amesMutagenicityTestPred\" : null,\n  \"pkaaOperaPred\"
-        : 3.06,\n  \"pkabOperaPred\" : -0.703,\n  \"dtxsid\" : \"DTXSID1020190\",\n
+      string: "{\n  \"id\" : 170313,\n  \"cpdataCount\" : 25,\n  \"inchikey\" : \"KHLVKKOJDHCJMG-UHFFFAOYSA-L\",\n
+        \ \"wikipediaArticle\" : \"Indigo_carmine\",\n  \"dtxsid\" : \"DTXSID1020190\",\n
         \ \"dtxcid\" : \"DTXCID801022742\",\n  \"casrn\" : \"860-22-0\",\n  \"compoundId\"
         : 1022742,\n  \"genericSubstanceId\" : 20190,\n  \"preferredName\" : \"C.I.
-        Acid Blue 74\",\n  \"activeAssays\" : 15,\n  \"molFormula\" : \"C16H8N2Na2O8S2\",\n
-        \ \"monoisotopicMass\" : 465.95174613,\n  \"percentAssays\" : 4.0,\n  \"pubchemCount\"
-        : 110,\n  \"pubmedCount\" : 836.0,\n  \"sourcesCount\" : 60,\n  \"qcLevel\"
+        Acid Blue 74\",\n  \"activeAssays\" : 18,\n  \"molFormula\" : \"C16H8N2Na2O8S2\",\n
+        \ \"monoisotopicMass\" : 465.95174613,\n  \"percentAssays\" : 5.0,\n  \"pubchemCount\"
+        : 110,\n  \"pubmedCount\" : 836.0,\n  \"sourcesCount\" : 67,\n  \"qcLevel\"
         : 1,\n  \"qcLevelDesc\" : \"Level 1: Expert curated, highest confidence in
         accuracy and consistency of unique chemical identifiers\",\n  \"stereo\" :
         \"0\",\n  \"isotope\" : 0,\n  \"multicomponent\" : 1,\n  \"totalAssays\" :
-        353,\n  \"toxcastSelect\" : \"15/353\",\n  \"pubchemCid\" : 2723854,\n  \"relatedSubstanceCount\"
-        : null,\n  \"relatedStructureCount\" : null,\n  \"hasStructureImage\" : 1,\n
-        \ \"iupacName\" : \"Disodium 3-oxo-2-(3-oxo-5-sulfonato-1,3-dihydro-2H-indol-2-ylidene)-2,3-dihydro-1H-indole-5-sulfonate\",\n
+        363,\n  \"toxcastSelect\" : \"18/363\",\n  \"pubchemCid\" : 2723854,\n  \"relatedSubstanceCount\"
+        : 2,\n  \"relatedStructureCount\" : 1,\n  \"hasStructureImage\" : 1,\n  \"iupacName\"
+        : \"Disodium 3-oxo-2-(3-oxo-5-sulfonato-1,3-dihydro-2H-indol-2-ylidene)-2,3-dihydro-1H-indole-5-sulfonate\",\n
         \ \"smiles\" : \"[Na+].[Na+].[O-]S(=O)(=O)C1=CC=C2NC(C(=O)C2=C1)=C1NC2=CC=C(C=C2C1=O)S([O-])(=O)=O\",\n
         \ \"inchiString\" : \"InChI=1S/C16H10N2O8S2.2Na/c19-15-9-5-7(27(21,22)23)1-3-11(9)17-13(15)14-16(20)10-6-8(28(24,25)26)2-4-12(10)18-14;;/h1-6,17-18H,(H,21,22,23)(H,24,25,26);;/q;2*+1/p-2\\n\",\n
         \ \"averageMass\" : 466.35,\n  \"qcNotes\" : \"Record was reviewed with Common
-        Chemistry.\\r\\n\",\n  \"qsarReadySmiles\" : \"OS(=O)(=O)C1=CC2=C(NC(C2=O)C2=NC3=C(C=C(C=C3)S(O)(=O)=O)C2=O)C=C1\",\n
-        \ \"expocatMedianPrediction\" : \"5.44E-03\",\n  \"expocat\" : \"Y\"\n}"
+        Chemistry.\\r\\n\",\n  \"qsarReadySmiles\" : null,\n  \"msReadySmiles\" :
+        null,\n  \"irisLink\" : null,\n  \"pprtvLink\" : null,\n  \"descriptorStringTsv\"
+        : \"0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t1\\t1\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t1\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t1\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\\t0\",\n
+        \ \"isMarkush\" : false,\n  \"expocatMedianPrediction\" : \"5.44E-03\",\n
+        \ \"expocat\" : \"Y\",\n  \"nhanes\" : \"0\",\n  \"toxvalData\" : \"Y\",\n
+        \ \"waterSolubilityTest\" : null,\n  \"waterSolubilityOpera\" : 0.164899,\n
+        \ \"viscosityCpCpTestPred\" : null,\n  \"vaporPressureMmhgTestPred\" : null,\n
+        \ \"vaporPressureMmhgOperaPred\" : 3.79111E-10,\n  \"thermalConductivity\"
+        : null,\n  \"tetrahymenaPyriformis\" : null,\n  \"surfaceTension\" : null,\n
+        \ \"soilAdsorptionCoefficient\" : 39.0955,\n  \"oralRatLd50Mol\" : null,\n
+        \ \"operaKmDaysOperaPred\" : 0.576138,\n  \"octanolWaterPartition\" : 0.962405,\n
+        \ \"octanolAirPartitionCoeff\" : 9.38377,\n  \"meltingPointDegcTestPred\"
+        : null,\n  \"meltingPointDegcOperaPred\" : 228.535,\n  \"hrFatheadMinnow\"
+        : null,\n  \"hrDiphniaLc50\" : null,\n  \"henrysLawAtm\" : 1.48644E-11,\n
+        \ \"flashPointDegcTestPred\" : null,\n  \"devtoxTestPred\" : null,\n  \"density\"
+        : null,\n  \"boilingPointDegcTestPred\" : null,\n  \"boilingPointDegcOperaPred\"
+        : 291.807,\n  \"biodegradationHalfLifeDays\" : 15.3519,\n  \"bioconcentrationFactorTestPred\"
+        : null,\n  \"bioconcentrationFactorOperaPred\" : 2.42942,\n  \"atmosphericHydroxylationRate\"
+        : 4.84144E-11,\n  \"amesMutagenicityTestPred\" : null,\n  \"pkaaOperaPred\"
+        : 3.06,\n  \"pkabOperaPred\" : -0.703\n}"
     headers:
+      Access-Control-Allow-Origin:
+      - '*'
       Cache-Control:
       - max-age=0, must-revalidate, no-transform
       Connection:
-      - keep-alive
+      - Keep-Alive
       Content-Type:
       - application/json
       Date:
-      - Thu, 05 Sep 2024 22:58:04 GMT
+      - Fri, 30 Jan 2026 15:02:52 GMT
+      Keep-Alive:
+      - timeout=5, max=1000
+      Server:
+      - Apache
       Strict-Transport-Security:
-      - max-age=31536000
+      - "max-age=63072000; includeSubDomains; preload\xE2\x80\x9C"
       Transfer-Encoding:
       - chunked
       Vary:
-      - Accept-Encoding
-      Via:
-      - 1.1 99baebf4b5bb631267dcfa82456151cc.cloudfront.net (CloudFront)
-      X-Amz-Cf-Id:
-      - JmvYOAQzL4sAlO2i58vfku19qQ91edOR98tbgnM02sFl_EepPQIhYQ==
-      X-Amz-Cf-Pop:
-      - IAD89-C1
-      X-Cache:
-      - Miss from cloudfront
-      X-Content-Type-Options:
-      - nosniff
-      X-Frame-Options:
-      - DENY
-      X-Vcap-Request-Id:
-      - 552e477e-1e94-4978-507c-3135946f8172
-      X-Xss-Protection:
-      - 1; mode=block
+      - Origin,Access-Control-Request-Method,Access-Control-Request-Headers
     status:
       code: 200
-      message: OK
+      message: ''
 version: 1
diff --git a/tests/data/cassettes/services.epa.test_dsstox/TestDssSubstance.test_bad_dsstox.yaml b/tests/data/cassettes/services.epa.test_dsstox/TestDssSubstance.test_bad_dsstox.yaml
@@ -5,50 +5,40 @@ interactions:
       Accept:
       - application/json
       Accept-Encoding:
-      - gzip, deflate
+      - gzip, deflate, zstd
       Connection:
       - keep-alive
       User-Agent:
       - hawc
       x-api-key:
       - <omitted>
     method: GET
-    uri: https://api-ccte.epa.gov/chemical/detail/search/by-dtxsid/DTXSID123456789
+    uri: https://comptox.epa.gov/ctx-api/chemical/detail/search/by-dtxsid/DTXSID123456789
   response:
     body:
       string: "{\n  \"type\" : \"about:blank\",\n  \"title\" : \"Bad Request\",\n
         \ \"status\" : 400,\n  \"detail\" : \"dtxsid with value DTXSID123456789 not
         found.\",\n  \"instance\" : \"/chemical/detail/search/by-dtxsid/DTXSID123456789\"\n}"
     headers:
+      Access-Control-Allow-Origin:
+      - '*'
       Cache-Control:
       - max-age=0, must-revalidate, no-transform
       Connection:
-      - keep-alive
+      - close
       Content-Type:
       - application/problem+json
       Date:
-      - Thu, 05 Sep 2024 23:00:48 GMT
+      - Fri, 30 Jan 2026 15:03:25 GMT
+      Server:
+      - Apache
       Strict-Transport-Security:
-      - max-age=31536000
+      - "max-age=63072000; includeSubDomains; preload\xE2\x80\x9C"
       Transfer-Encoding:
       - chunked
-      Via:
-      - 1.1 5eb5e19c1a78889d10ff38f1551ed2aa.cloudfront.net (CloudFront)
-      X-Amz-Cf-Id:
-      - QkxUHQsw5P2OEfQguc-yW3T0fJuxR3T7mwIQcBFFi_Zu3pXZ8dC-Ug==
-      X-Amz-Cf-Pop:
-      - IAD89-C1
-      X-Cache:
-      - Error from cloudfront
-      X-Content-Type-Options:
-      - nosniff
-      X-Frame-Options:
-      - DENY
-      X-Vcap-Request-Id:
-      - cc08d157-3ec9-40e6-4b23-cbdac3417363
-      X-Xss-Protection:
-      - 1; mode=block
+      Vary:
+      - Origin,Access-Control-Request-Method,Access-Control-Request-Headers
     status:
       code: 400
-      message: Bad Request
+      message: ''
 version: 1