From b2959c91d01073a96d662c9d30ae99d65f42bdb6 Mon Sep 17 00:00:00 2001 From: mite-bot Date: Wed, 6 May 2026 19:20:16 +0200 Subject: [PATCH 1/7] Add submission UUID file --- .../90b20386-496f-11f1-9ef6-bb4e59819b6d.json | 44 +++++++++++++++++++ 1 file changed, 44 insertions(+) create mode 100644 mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json diff --git a/mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json b/mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json new file mode 100644 index 000000000..7514571cf --- /dev/null +++ b/mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json @@ -0,0 +1,44 @@ +{ + "accession": "MITE9999999", + "status": "pending", + "changelog": [ + { + "version": "1", + "date": "2026-05-06", + "contributors": [ + "0009-0008-4645-6771" + ], + "reviewers": [ + "BBBBBBBBBBBBBBBBBBBBBBBB" + ], + "comment": "New entry." + } + ], + "enzyme": { + "name": "PhomQ2", + "databaseIds": { + "uniprot": "A0A8J9RRY2", + "genpept": "" + }, + "references": [ + "doi:" + ] + }, + "reactions": [ + { + "evidence": { + "evidenceCode": [], + "references": [ + "doi:" + ] + }, + "reactions": [ + { + "products": [ + "" + ] + } + ] + } + ] +} \ No newline at end of file From ca3420f61c606edf3f0f92dae3aac29cc9212175 Mon Sep 17 00:00:00 2001 From: mite-bot Date: Wed, 6 May 2026 19:24:29 +0200 Subject: [PATCH 2/7] Update submission --- .../90b20386-496f-11f1-9ef6-bb4e59819b6d.json | 43 +++++++++++++------ 1 file changed, 30 insertions(+), 13 deletions(-) diff --git a/mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json b/mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json index 7514571cf..18a2da314 100644 --- a/mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json +++ b/mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json @@ -1,6 +1,7 @@ { "accession": "MITE9999999", "status": "pending", + "comment": "Tyrosinase-like protein", "changelog": [ { "version": "1", @@ -16,29 +17,45 @@ ], "enzyme": { "name": "PhomQ2", + "description": "Hydroxylase", + "references": [ + "doi:10.1002/anie.202111076" + ], "databaseIds": { "uniprot": "A0A8J9RRY2", - "genpept": "" + "genpept": "BDA39150.1", + "mibig": "BGC0001398" }, - "references": [ - "doi:" - ] + "cofactors": { + "inorganic": [ + "Cu" + ] + } }, "reactions": [ { - "evidence": { - "evidenceCode": [], - "references": [ - "doi:" - ] - }, + "tailoring": [ + "Hydroxylation" + ], + "description": "Hydroxylation of the tyrosine moiety.", + "reactionSMARTS": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O>>CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cc(O)c(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O", "reactions": [ { + "substrate": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O", "products": [ - "" - ] + "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cc(O)c(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O" + ], + "isIntermediate": false } - ] + ], + "evidence": { + "evidenceCode": [ + "Knock-out studies" + ], + "references": [ + "doi:10.1002/anie.202111076" + ] + } } ] } \ No newline at end of file From b94bbb3e7c90eb392d542b1937da74f74eb91fda Mon Sep 17 00:00:00 2001 From: mite-bot Date: Wed, 22 Jul 2026 16:19:15 +0200 Subject: [PATCH 3/7] Delete mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json --- .../90b20386-496f-11f1-9ef6-bb4e59819b6d.json | 61 ------------------- 1 file changed, 61 deletions(-) delete mode 100644 mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json diff --git a/mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json b/mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json deleted file mode 100644 index 18a2da314..000000000 --- a/mite_data/data/90b20386-496f-11f1-9ef6-bb4e59819b6d.json +++ /dev/null @@ -1,61 +0,0 @@ -{ - "accession": "MITE9999999", - "status": "pending", - "comment": "Tyrosinase-like protein", - "changelog": [ - { - "version": "1", - "date": "2026-05-06", - "contributors": [ - "0009-0008-4645-6771" - ], - "reviewers": [ - "BBBBBBBBBBBBBBBBBBBBBBBB" - ], - "comment": "New entry." - } - ], - "enzyme": { - "name": "PhomQ2", - "description": "Hydroxylase", - "references": [ - "doi:10.1002/anie.202111076" - ], - "databaseIds": { - "uniprot": "A0A8J9RRY2", - "genpept": "BDA39150.1", - "mibig": "BGC0001398" - }, - "cofactors": { - "inorganic": [ - "Cu" - ] - } - }, - "reactions": [ - { - "tailoring": [ - "Hydroxylation" - ], - "description": "Hydroxylation of the tyrosine moiety.", - "reactionSMARTS": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O>>CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cc(O)c(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O", - "reactions": [ - { - "substrate": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O", - "products": [ - "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cc(O)c(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O" - ], - "isIntermediate": false - } - ], - "evidence": { - "evidenceCode": [ - "Knock-out studies" - ], - "references": [ - "doi:10.1002/anie.202111076" - ] - } - } - ] -} \ No newline at end of file From 39e290b533684e72ae2154db05c121f8b608fc79 Mon Sep 17 00:00:00 2001 From: mite-bot Date: Wed, 22 Jul 2026 16:19:17 +0200 Subject: [PATCH 4/7] Add submission --- mite_data/data/MITE9999999.json | 63 +++++++++++++++++++++++++++++++++ 1 file changed, 63 insertions(+) create mode 100644 mite_data/data/MITE9999999.json diff --git a/mite_data/data/MITE9999999.json b/mite_data/data/MITE9999999.json new file mode 100644 index 000000000..bc47c2aca --- /dev/null +++ b/mite_data/data/MITE9999999.json @@ -0,0 +1,63 @@ +{ + "accession": "MITE9999999", + "status": "active", + "comment": "Tyrosinase-like protein, also annotated as Oxidoreductase that oxidases/hydroxylates the tyrosine", + "changelog": [ + { + "version": "1", + "date": "2026-05-06", + "contributors": [ + "0009-0008-4645-6771" + ], + "reviewers": [ + "0000-0002-9747-3423" + ], + "comment": "New entry." + } + ], + "enzyme": { + "name": "PhomQ2", + "description": "Monooxygenase, Oxidoreductase", + "references": [ + "doi:10.1002/anie.202111076" + ], + "databaseIds": { + "uniprot": "A0A8J9RRY2", + "genpept": "BDA39150.1", + "mibig": "BGC0001398" + }, + "cofactors": { + "inorganic": [ + "Cu" + ] + } + }, + "reactions": [ + { + "tailoring": [ + "Hydroxylation", + "Oxidation" + ], + "description": "Hydroxylation of the tyrosine moiety", + "reactionSMARTS": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O>>CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cc(O)c(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O", + "reactions": [ + { + "substrate": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O", + "products": [ + "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cc(O)c(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O" + ], + "isIntermediate": false, + "description": "Hydroxylation of the tyrosine moiety" + } + ], + "evidence": { + "evidenceCode": [ + "Knock-out studies" + ], + "references": [ + "doi:10.1002/anie.202111076" + ] + } + } + ] +} \ No newline at end of file From 93e165810689cac759a62da2333949a4648c0783 Mon Sep 17 00:00:00 2001 From: "Mitja M. Zdouc" <95709447+mmzdouc@users.noreply.github.com> Date: Thu, 1 Oct 2026 13:16:33 +0200 Subject: [PATCH 5/7] Update and rename MITE9999999.json to MITE0000482.json --- mite_data/data/{MITE9999999.json => MITE0000482.json} | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) rename mite_data/data/{MITE9999999.json => MITE0000482.json} (98%) diff --git a/mite_data/data/MITE9999999.json b/mite_data/data/MITE0000482.json similarity index 98% rename from mite_data/data/MITE9999999.json rename to mite_data/data/MITE0000482.json index bc47c2aca..b117c245d 100644 --- a/mite_data/data/MITE9999999.json +++ b/mite_data/data/MITE0000482.json @@ -1,5 +1,5 @@ { - "accession": "MITE9999999", + "accession": "MITE0000482", "status": "active", "comment": "Tyrosinase-like protein, also annotated as Oxidoreductase that oxidases/hydroxylates the tyrosine", "changelog": [ @@ -60,4 +60,4 @@ } } ] -} \ No newline at end of file +} From be875df6dc32029a23ca95242978365deac4042e Mon Sep 17 00:00:00 2001 From: "Mitja M. Zdouc" <95709447+mmzdouc@users.noreply.github.com> Date: Thu, 1 Oct 2026 13:25:41 +0200 Subject: [PATCH 6/7] Update MITE0000482.json --- mite_data/data/MITE0000482.json | 7 ++++--- 1 file changed, 4 insertions(+), 3 deletions(-) diff --git a/mite_data/data/MITE0000482.json b/mite_data/data/MITE0000482.json index b117c245d..4c3c56b5a 100644 --- a/mite_data/data/MITE0000482.json +++ b/mite_data/data/MITE0000482.json @@ -10,9 +10,10 @@ "0009-0008-4645-6771" ], "reviewers": [ - "0000-0002-9747-3423" + "0000-0002-9747-3423", + "0000-0001-6534-6609" ], - "comment": "New entry." + "comment": "New entry. Reviewer 2 changed reaction SMILES to reaction SMARTS." } ], "enzyme": { @@ -39,7 +40,7 @@ "Oxidation" ], "description": "Hydroxylation of the tyrosine moiety", - "reactionSMARTS": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O>>CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cc(O)c(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O", + "reactionSMARTS": "[#6:1]-[#6:2]-[#6@@:3](-[#6@@:5](\[#6:42](-[#7:44]/[#6@:45](-[#6:50](-[#8:52])=[#8:51])-[#6:46]-[#6:47](-[#8:49])=[#8:48])=[#8:43])-[#7:6]-[#6:7](/[#6@:9]1-[#7:13](-[#6:14](/[#6@:16](-[#6@:38](-[#6:40]-[#6:41])/[#6:39])-[#7:17]-[#6:18](\[#6@:20](-[#6:35](-[#6:37])-[#6:36])-[#7:21]-[#6:22](-[#6@:24](-[#6:26]-[#6:27]2:[#6:34]:[#6:32](-Cl:33):[#6:30](-[#8:31]):[#6:29]:[#6:28]:2)\[#7:25])=[#8:23])=[#8:19])=[#8:15])-[#6:12]-[#6:11]-[#6:10]-1)=[#8:8])\[#6:4]>>[#6:1]-[#6:2]-[#6@@:3](-[#6@@:5](\[#6:42](-[#7:44]/[#6@:45](-[#6:50](-[#8:52])=[#8:51])-[#6:46]-[#6:47](-[#8:49])=[#8:48])=[#8:43])-[#7:6]-[#6:7](/[#6@:9]1-[#7:13](-[#6:14](/[#6@:16](-[#6@:38](-[#6:40]-[#6:41])/[#6:39])-[#7:17]-[#6:18](\[#6@:20](-[#6:35](-[#6:36])-[#6:37])-[#7:21]-[#6:22](-[#6@:24](-[#6:26]-[#6:27]2:[#6:34]:[#6:32](-Cl:33):[#6:30](-[#8:31]):[#6:29](-[#8]):[#6:28]:2)\[#7:25])=[#8:23])=[#8:19])=[#8:15])-[#6:12]-[#6:11]-[#6:10]-1)=[#8:8])\[#6:4]", "reactions": [ { "substrate": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O", From ec7bdca4595853515d62eb0491330f412adc25a6 Mon Sep 17 00:00:00 2001 From: "Mitja M. Zdouc" <95709447+mmzdouc@users.noreply.github.com> Date: Thu, 1 Oct 2026 13:44:51 +0200 Subject: [PATCH 7/7] Update MITE0000482.json --- mite_data/data/MITE0000482.json | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/mite_data/data/MITE0000482.json b/mite_data/data/MITE0000482.json index 4c3c56b5a..04ceb5546 100644 --- a/mite_data/data/MITE0000482.json +++ b/mite_data/data/MITE0000482.json @@ -40,7 +40,7 @@ "Oxidation" ], "description": "Hydroxylation of the tyrosine moiety", - "reactionSMARTS": "[#6:1]-[#6:2]-[#6@@:3](-[#6@@:5](\[#6:42](-[#7:44]/[#6@:45](-[#6:50](-[#8:52])=[#8:51])-[#6:46]-[#6:47](-[#8:49])=[#8:48])=[#8:43])-[#7:6]-[#6:7](/[#6@:9]1-[#7:13](-[#6:14](/[#6@:16](-[#6@:38](-[#6:40]-[#6:41])/[#6:39])-[#7:17]-[#6:18](\[#6@:20](-[#6:35](-[#6:37])-[#6:36])-[#7:21]-[#6:22](-[#6@:24](-[#6:26]-[#6:27]2:[#6:34]:[#6:32](-Cl:33):[#6:30](-[#8:31]):[#6:29]:[#6:28]:2)\[#7:25])=[#8:23])=[#8:19])=[#8:15])-[#6:12]-[#6:11]-[#6:10]-1)=[#8:8])\[#6:4]>>[#6:1]-[#6:2]-[#6@@:3](-[#6@@:5](\[#6:42](-[#7:44]/[#6@:45](-[#6:50](-[#8:52])=[#8:51])-[#6:46]-[#6:47](-[#8:49])=[#8:48])=[#8:43])-[#7:6]-[#6:7](/[#6@:9]1-[#7:13](-[#6:14](/[#6@:16](-[#6@:38](-[#6:40]-[#6:41])/[#6:39])-[#7:17]-[#6:18](\[#6@:20](-[#6:35](-[#6:36])-[#6:37])-[#7:21]-[#6:22](-[#6@:24](-[#6:26]-[#6:27]2:[#6:34]:[#6:32](-Cl:33):[#6:30](-[#8:31]):[#6:29](-[#8]):[#6:28]:2)\[#7:25])=[#8:23])=[#8:19])=[#8:15])-[#6:12]-[#6:11]-[#6:10]-1)=[#8:8])\[#6:4]", + "reactionSMARTS": "[#6:1]-[#6:2]-[#6@@:3](-[#6@@:5](\\[#6:42](-[#7:44]/[#6@:45](-[#6:50](-[#8:52])=[#8:51])-[#6:46]-[#6:47](-[#8:49])=[#8:48])=[#8:43])-[#7:6]-[#6:7](/[#6@:9]1-[#7:13](-[#6:14](/[#6@:16](-[#6@:38](-[#6:40]-[#6:41])/[#6:39])-[#7:17]-[#6:18](\\[#6@:20](-[#6:35](-[#6:37])-[#6:36])-[#7:21]-[#6:22](-[#6@:24](-[#6:26]-[#6:27]2:[#6:34]:[#6:32](-Cl:33):[#6:30](-[#8:31]):[#6:29]:[#6:28]:2)\\[#7:25])=[#8:23])=[#8:19])=[#8:15])-[#6:12]-[#6:11]-[#6:10]-1)=[#8:8])\\[#6:4]>>[#6:1]-[#6:2]-[#6@@:3](-[#6@@:5](\\[#6:42](-[#7:44]/[#6@:45](-[#6:50](-[#8:52])=[#8:51])-[#6:46]-[#6:47](-[#8:49])=[#8:48])=[#8:43])-[#7:6]-[#6:7](/[#6@:9]1-[#7:13](-[#6:14](/[#6@:16](-[#6@:38](-[#6:40]-[#6:41])/[#6:39])-[#7:17]-[#6:18](\\[#6@:20](-[#6:35](-[#6:36])-[#6:37])-[#7:21]-[#6:22](-[#6@:24](-[#6:26]-[#6:27]2:[#6:34]:[#6:32](-Cl:33):[#6:30](-[#8:31]):[#6:29](-[#8]):[#6:28]:2)\\[#7:25])=[#8:23])=[#8:19])=[#8:15])-[#6:12]-[#6:11]-[#6:10]-1)=[#8:8])\\[#6:4]", "reactions": [ { "substrate": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O",