diff --git a/mite_data/data/MITE0000487.json b/mite_data/data/MITE0000487.json new file mode 100644 index 000000000..84775054b --- /dev/null +++ b/mite_data/data/MITE0000487.json @@ -0,0 +1,59 @@ +{ + "accession": "MITE0000487", + "status": "active", + "comment": "SDR-mediated oxidation of the 8S hydroxy group to a ketone in higginsianin biosynthesis", + "changelog": [ + { + "version": "1", + "date": "2026-05-06", + "contributors": [ + "0000-0002-0771-9611" + ], + "reviewers": [ + "0000-0002-4540-6501" + ], + "comment": "New entry. Reviewer 1 changed UniPort ID." + } + ], + "enzyme": { + "name": "dpchG", + "description": "Short chain dehydrogenase/reductase", + "references": [ + "doi:10.1038/s41467-020-15664-4" + ], + "databaseIds": { + "uniprot": "H1VN83" + }, + "cofactors": { + "organic": [ + "NADP" + ] + } + }, + "reactions": [ + { + "tailoring": [ + "Oxidation" + ], + "description": "SDR-mediated oxidation of the 8S hydroxy group to a ketone in higginsianin biosynthesis", + "reactionSMARTS": "C=C1CC[C@@H]2[C@](C)(CC[C@H](O)[C@@]2(C)CCC=C(C)C)[C@@H]1Cc1c(O)c(C)c(C)oc1=O>>C=C1CC[C@@H]2[C@](C)(CCC(=O)[C@@]2(C)CCC=C(C)C)[C@@H]1Cc1c(O)c(C)c(C)oc1=O", + "reactions": [ + { + "substrate": "C=C1CC[C@@H]2[C@](C)(CC[C@H](O)[C@@]2(C)CCC=C(C)C)[C@@H]1Cc1c(O)c(C)c(C)oc1=O", + "products": [ + "C=C1CC[C@@H]2[C@](C)(CCC(=O)[C@@]2(C)CCC=C(C)C)[C@@H]1Cc1c(O)c(C)c(C)oc1=O" + ], + "isIntermediate": true + } + ], + "evidence": { + "evidenceCode": [ + "Heterologous expression" + ], + "references": [ + "doi:10.1038/s41467-020-15664-4" + ] + } + } + ] +}