diff --git a/pkg/controllers/resources/pods/translate/translator.go b/pkg/controllers/resources/pods/translate/translator.go
index 7b8dbf3959..369536258a 100644
--- a/pkg/controllers/resources/pods/translate/translator.go
+++ b/pkg/controllers/resources/pods/translate/translator.go
@@ -7,6 +7,7 @@ import (
 	"path"
 	"path/filepath"
 	"regexp"
+	"slices"
 	"sort"
 	"strconv"
 	"strings"
@@ -916,6 +917,7 @@ func (t *translator) translateResourceClaims(ctx *synccontext.SyncContext, pPod
 
 func translateTopologySpreadConstraints(vPod *corev1.Pod, pPod *corev1.Pod) {
 	for i := range pPod.Spec.TopologySpreadConstraints {
+		sanitizeMatchLabelKeysSelector(vPod, &pPod.Spec.TopologySpreadConstraints[i])
 		pPod.Spec.TopologySpreadConstraints[i].LabelSelector = translate.HostLabelSelector(pPod.Spec.TopologySpreadConstraints[i].LabelSelector)
 
 		// make sure we only select pods in the current namespace
@@ -929,6 +931,34 @@ func translateTopologySpreadConstraints(vPod *corev1.Pod, pPod *corev1.Pod) {
 	}
 }
 
+func sanitizeMatchLabelKeysSelector(_ *corev1.Pod, constraint *corev1.TopologySpreadConstraint) {
+	if constraint.LabelSelector == nil || len(constraint.MatchLabelKeys) == 0 || len(constraint.LabelSelector.MatchExpressions) == 0 {
+		return
+	}
+
+	matchExpressions := constraint.LabelSelector.MatchExpressions[:0]
+	for _, requirement := range constraint.LabelSelector.MatchExpressions {
+		if shouldStripMatchLabelKeysRequirement(constraint.MatchLabelKeys, requirement) {
+			continue
+		}
+
+		matchExpressions = append(matchExpressions, requirement)
+	}
+
+	if len(matchExpressions) == 0 {
+		constraint.LabelSelector.MatchExpressions = nil
+		return
+	}
+
+	constraint.LabelSelector.MatchExpressions = matchExpressions
+}
+
+func shouldStripMatchLabelKeysRequirement(matchLabelKeys []string, requirement metav1.LabelSelectorRequirement) bool {
+	return requirement.Operator == metav1.LabelSelectorOpIn &&
+		len(requirement.Values) == 1 &&
+		slices.Contains(matchLabelKeys, requirement.Key)
+}
+
 func ServicesToEnvironmentVariables(enableServiceLinks *bool, services []*corev1.Service, kubeIP string) map[string]string {
 	var (
 		serviceMap = make(map[string]*corev1.Service)
diff --git a/pkg/controllers/resources/pods/translate/translator_test.go b/pkg/controllers/resources/pods/translate/translator_test.go
index db8aa21786..0a9a585067 100644
--- a/pkg/controllers/resources/pods/translate/translator_test.go
+++ b/pkg/controllers/resources/pods/translate/translator_test.go
@@ -183,6 +183,72 @@ type translatePodAffinityTermTestCase struct {
 	expectedEvents []string
 }
 
+func TestTranslateTopologySpreadConstraints(t *testing.T) {
+	vPod := &corev1.Pod{
+		ObjectMeta: metav1.ObjectMeta{
+			Namespace: "test-ns",
+			Labels: map[string]string{
+				"app":               "demo",
+				"pod-template-hash": "def456",
+			},
+		},
+	}
+	pPod := &corev1.Pod{
+		Spec: corev1.PodSpec{
+			TopologySpreadConstraints: []corev1.TopologySpreadConstraint{
+				{
+					MaxSkew:           1,
+					TopologyKey:       "kubernetes.io/hostname",
+					WhenUnsatisfiable: corev1.ScheduleAnyway,
+					MatchLabelKeys:    []string{"pod-template-hash"},
+					LabelSelector: &metav1.LabelSelector{
+						MatchLabels: map[string]string{
+							"app": "demo",
+						},
+						MatchExpressions: []metav1.LabelSelectorRequirement{
+							{
+								Key:      "pod-template-hash",
+								Operator: metav1.LabelSelectorOpIn,
+								Values:   []string{"abc123"},
+							},
+							{
+								Key:      "existing",
+								Operator: metav1.LabelSelectorOpIn,
+								Values:   []string{"value"},
+							},
+						},
+					},
+				},
+			},
+		},
+	}
+
+	translateTopologySpreadConstraints(vPod, pPod)
+
+	assert.Assert(t, cmp.DeepEqual(pPod.Spec.TopologySpreadConstraints, []corev1.TopologySpreadConstraint{
+		{
+			MaxSkew:           1,
+			TopologyKey:       "kubernetes.io/hostname",
+			WhenUnsatisfiable: corev1.ScheduleAnyway,
+			MatchLabelKeys:    []string{"pod-template-hash"},
+			LabelSelector: &metav1.LabelSelector{
+				MatchLabels: map[string]string{
+					"app":                    "demo",
+					translate.NamespaceLabel: "test-ns",
+					translate.MarkerLabel:    translate.VClusterName,
+				},
+				MatchExpressions: []metav1.LabelSelectorRequirement{
+					{
+						Key:      "existing",
+						Operator: metav1.LabelSelectorOpIn,
+						Values:   []string{"value"},
+					},
+				},
+			},
+		},
+	}))
+}
+
 func TestVolumeTranslation(t *testing.T) {
 	virtualPath := fmt.Sprintf(VirtualPathTemplate, testingutil.DefaultTestCurrentNamespace, testingutil.DefaultTestVClusterName)
 	hostToContainer := corev1.MountPropagationHostToContainer