diff --git a/crates/bevy_render/src/settings.rs b/crates/bevy_render/src/settings.rs
index 9db9489d21048..07eff236f5f7d 100644
--- a/crates/bevy_render/src/settings.rs
+++ b/crates/bevy_render/src/settings.rs
@@ -129,7 +129,18 @@ impl Default for WgpuSettings {
 
         let mut instance_flags = InstanceFlags::default();
         #[cfg(not(debug_assertions))]
+        {
+            // wgpu executes additional necessary logic during validation passes for the DX12 backend,
+            // so the `VALIDATION_INDIRECT_CALL` flag should stay for DX12.
+            if !backends.is_some_and(|backends| backends.contains(Backends::DX12)) {
+                // Removing this flag improves performance.
+                instance_flags.remove(InstanceFlags::VALIDATION_INDIRECT_CALL);
+            }
+        }
+        #[cfg(all(not(debug_assertions), feature = "raw_vulkan_init"))]
+        // intending to use vulkan even if backends may contain DX12
         instance_flags.remove(InstanceFlags::VALIDATION_INDIRECT_CALL);
+
         instance_flags = instance_flags.with_env();
 
         Self {